The most spontaneous and immediate way of making an image in printmaking. Draw or paint directly onto a substrate and print using a press or by hand. As the name implies, a mono print is a unique image that cannot be identically repeated. It has been referred to as the "painter's print".

The difference between a monotype and a mono print, traditionally, is that a mono print will have some kind of repeatable matrix, for example, a lino block or a screen print stencil. A monotype has no repeatable matrix, as the artist will make their marks on a plate or another substrate much like a drawing or a painting. This is a one-of-a-kind impression.